Measure Lithium in clinical samples

Flame Photometer

  • Operator selectable Caesium or Lithium internal reference.
  • On board firmware with digital blanking.
  • Simultaneous measurement of up to two of three available elements (Sodium, Potassium and/or Lithium)

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Why buy from Geneq? - find out more

The Model 420Cs is the latest addition to our dual channel Flame Photometer range. 

Based on the Model 420 Flame Photometer, the M420Cs add greater flexibility and also benefit from recent improvements to stability (precision) available on all of the Sherwood 420 Series and 410 Series of Flame Photometers since January 2017.
Unique to the Sherwood range, the M420Cs Flame Photometer comes with a Caesium reference channel as an alternative to the existing Lithium reference channel traditionally used in Corning and then Sherwood instruments. 
The Caesium Reference facility provides greater flexibility; allowing the operator to choose the internal reference element based on sample matrix considerations or to match established procedures developed with other instruments, e.g. the IL 943 Flame Photometer.
A primary practical example where Caesium is beneficial as an internal reference is the ability to measure Lithium in clinical samples with the increased precision afforded by the use of an internal reference method.

The M420Cs Flame Photometer features:

    • Operator selectable Caesium or Lithium internal reference.
    • On board firmware with digital blanking, calibration and sampling routines greatly increase calibration speed and sample throughput.
    • Simultaneous measurement of up to two of three available elements (Sodium, Potassium and/or Lithium).
    • Linearised Sodium response over the expected clinical Sodium concentration range (following a 1 in 200 dilutions).
    • Improved precision with the internal reference facility (<0.5%CV for aqueous standard solutions).
    • Robust safety features include flame detection and gas safety shut-off with low air pressure.
    • Two in-built digital displays for calibration and analysis data of each channel, analogue output connectors for use with chart recorders and some online analysis systems.
    • A “no tools” maintenance approach allows for easy access to and cleaning of the mixing chamber and burner assembly.
    • RS232 for data output to a printer or PC when installed with the Regulated BlueNotes 420 Software package.

    Regulated BlueNotes 420 Software

    Regulated BlueNotes 420 Software is designed to provide features that enable users to operate in a manner compliant with data handling standards such as 21 CFR Part 11. The software expands the functionality of the Model 420Cs Flame Photometer; allowing data collection from all three element detector channels simultaneously in one sample sequence. 

    There is also the option to configure the software to use Potassium as an internal reference channel in addition to the Caesium (default) or Lithium channels.

    Regulated features include:

    • A three-tier login system with different levels of access. (Operator, Supervisor and Administrator)
    • Unique user names and passwords for every user.
    • Audit trails record all operations with detailed information concerning the user and the software version, Windows version and PC name to ensure traceability and accountability.
    • Robust data file system which is tampering evident and inaccessible to users without elevated Windows privileges.
    • Tamper evident data format is used for analysis results, system configuration and method files to ensure data integrity.
    • Auto-generated PDF analysis reports provide a comprehensive summary of all information relevant to an analysis run in one clear and concise document.
    Measurement RangeLinearity
    Na Serum110.0 to 170.0 mmol/lNa SerumNa Serum within ± 2 mmol/l
    Na Urine0.0 to 199.9 mmol/lNa UrineNa Urine within ± 4 mmol/l
    K Serum0.00 to 10.00 mmol/lK SerumK Serum within ± 0.2 mmol/l
    K Urine0.0 to 200.0 mmol/lK UrineK Urine within   ± 2 mmol/l
    Li Serum0.00 to 3.00 mmol/lLi SerumLi Serum within ± 0.2 mmol/l
    ReproducibilityDilution Factor
    Na (140.0 mmol/l) with de-ionised water< 0.5% CV (w/ Ref Facility)Na Serum/Urine1 in 200
    K (5.00 mmol/l) ionised water< 0.5% CV (w/ Ref Facility)K Serum1 in 200 with de-
    K (80.0 mmol/l) ionised water< 0.5% CV (w/ Ref Facility)K Urine1 in 200 with de-
    Li (1.50 mmol/l) ionised water< 0.5% CV (w/ Ref Facility)Li Serum1 in 50 with de-

    The above is correct for use with Propane. Results obtained from 20 replicates of the same sample, aspirating sample for 20 seconds, then water for 10 seconds. To achieve the stated specification the flame must be alight for a minimum of 30 minutes, with diluent (containing Diluent Concentrate) being aspirated.